The A142 at Mepal re-opened more than 12 hours after a collision which left one person dead and four others injured.
The road was closed between Sutton and Block Fen after police were called to reports of a serious collision at 6am.
Cambridgeshire Fire & Rescue crews from Ely, Manea and Chatteris were then called to the scene at 6.04am.
A Cambs Fire spokesman said: “Firefighters stabilised the vehicles and used specialist cutting equipment to release two casualties.
“Crews returned to their stations by 1.15pm.”
Fenland Police tweeted at 7.25pm last night: “#a142 #mepal now open following earlier RTC.”
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here