The drought-damaged B1040 between Whittlesey and Pondersbridge will be closed for three weeks from today (August 28).
The 24-hour closure in both directions will see major repairs to the surface of the road which has been affected by extreme weather conditions earlier this year.
A diversion will be in place along Ramsey Road, Toll Road and Kings Delph.
In total 21 sections of road across Peterborough, Fenland and East Cambridgeshire are being repaired following a successful £3.5 million funding bid to the government.
Both local councils topped this up to create a £6.25 million package that meant all the improvements could be carried through in a relatively short period of time.
Many of the Peterborough schemes have either been started or completed.
The B1040 St Marys Road in Ramsey will be closed from September 20 for three weeks, followed by B1096 in Benwick Road on October 12 for a month.
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